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Gene: Type in the name(s) of the gene or genes of interest, separated by a space, to filter variants. Moon takes into account every possible synonym or previous name of a gene based on the entered search. Gene names that are not recognised are highlighted in red. Unrecognised gene names are not taken into account for filtering.
Effect: Specify on or more variant effects to be displayed as a result of filtering. By default, ‘non-synonymous coding' and ‘splicing’ are selected as Effects. A few combination effects are also available for filtering, that already combine some separate variant effects:
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Disorder: This field allows to enter a disorder name of interest. All variants annotated with an Apollo disorder of which the Apollo disorder name contains the exact searched text, will be displayed. The checkbox below, allows to only display variants for which an Apollo disorder was annotated in the most recent analysis. To only display variants in genes with no disorder annotation, “No associated disorder” can be used as search term in the Disorder search field.
The inheritance filter allows you to select only variants that are annotated with an Apollo disorder with the inheritance pattern of interest. This filter can be combined with the ‘zygosity’ filter to view variants for which there is concordance between genotype and known inheritance (eg. Homozygous variants in genes associated with an autosomal recessive disorder).
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