With new genetic knowledge on rare diseases being published every day, it is possible that an undiagnosed patient might receive a diagnosis later on, based on this new information. As the annotation sources used by Moon are constantly updated, reanalysing your samples might thus yield additional diagnoses over time.
Manual reanalysis
The Reanalysis button at the top right of the Shortlist screen allows you to reanalyse a specific sample of interest, either with the original or updated patient information. Samples in which reanalysis yields new relevant findings or new variant classifications, are highlighted in green both in the sample overview screen and in the analysis screen. After manually checking the new results, these can be marked as reviewed.
Autopilot
Once the NGS data and patient info are provided, Moon can automatically reanalyse samples in the background without the need for manual intervention.
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Reanalysis can also be automated through the API.
Reanalysis & Autopilot settings
Admins can define different settings using the Reanalysis & Autopilot page, including:
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Which samples to regularly reanalyse
The time frame for automated reanalysis
Whether you would like the assigned scientist to receive an email notification for cases where results/classifications are different from the previous analysis
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Time Machine
For each sample, you can review the results and reports for all analyses performed over time. Via the menu at the bottom of the Shortlist screen, an analysis of choice can be selected. Previous results are displayed similarly to results from new analyses. The patient info for previous analyses is displayed based on the info that was inputted in Moon at the time of that specific analysis.
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